Diabetes mellitus is one of the prime risk factors for cardiovascular complications and is
linked with high morbidity and mortality. Diabetic cardiomyopathy (DCM) often manifests as …

Due to their different biological functions, extracellular vesicles (EVs) have great potential
from a therapeutic point of view. They are released by all cell types, carrying and delivering …

Rationale: After myocardial ischemic injury, improper phagocytic clearance of dying cardiac
cells and the ensuing lack of inflammation resolution results in adverse cardiac remodeling …

The inclusion of microRNAs (miRNAs) in extracellular microvesicles/exosomes (named
cardiosomes when deriving from cardiomyocytes) allows their active transportation and …

Several anticancer agents have been associated with cardiac toxic effects. The currently
proposed mechanisms to explain cardiotoxicity differ among anticancer agents, but in fact …

Cardiovascular diseases (CVDs) are the leading cause of human death worldwide.
Exosomes act as endogenous biological vectors; they possess advantages of low …

Although tissue-type plasminogen activator was approved by the FDA for early reperfusion
of occluded vessels, there is a need for an effective neuroprotective drug for stroke patients …

Background: Endothelial cells (ECs) play a critical role in the maintenance of vascular
homeostasis and in heart function. It was shown that activated fibroblast-derived exosomes …

Exosomes are a subgroup of extracellular bilayer membrane nanovesicles that are enriched
in a variety of bioactive lipids, receptors, transcription factors, surface proteins, DNA, and …

Sterol response element binding protein (SREBP) is a master regulator of cellular
lipogenesis. One key step in the regulation of SREBP activity is its sequential cleavage and …