Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by the
deficient production, secretion or action of gonadotropin-releasing hormone (GnRH), which …

Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …

Background The timing of puberty in girls is occurring at an increasingly early age. While a
positive family history is recognised as a predisposing factor for early or precocious puberty …

Background A secular trend towards earlier puberty has been observed in girls, while a
similar trend has been more uncertain in boys. We estimated current ages at pubertal …

The onset of puberty in adolescents and whether it is related to obesity is an ongoing topic
for debate. Epidemiological cross-sectional and longitudinal studies show a shift towards …

Puberty is accompanied by physical, psychological, and emotional changes adapted to
ensure reproductive and parenting success. Human puberty stands out in the animal world …

The decline in age at puberty in the general population has been paralleled by an increase
in the number of girls referred for evaluation of precocious puberty (PP). In 1999, The …

OBJECTIVE. Recent publications showing unexpectedly early breast development in
American girls created debate worldwide. However, secular trend analyses are often limited …

Since the early 1980s, the focus on the importance of puberty to adolescent development
has continued with variability in the methodology selected to measure puberty. To capture …

Whether children, especially girls, are entering and progressing through puberty earlier
today than in the mid-1900s has been debated. Secular trend analysis, based on available …