Personal utility in genomic testing: a systematic literature review
JN Kohler, E Turbitt, BB Biesecker - European Journal of Human …, 2017 - nature.com
Researchers and clinicians refer to outcomes of genomic testing that extend beyond clinical
utility as 'personal utility'. No systematic delineation of personal utility exists, making it …
utility as 'personal utility'. No systematic delineation of personal utility exists, making it …
Evolving health care through personal genomics
HL Rehm - Nature Reviews Genetics, 2017 - nature.com
With the rapid evolution of next-generation DNA sequencing technologies, the cost of
sequencing a human genome has plummeted, and genomics has started to pervade health …
sequencing a human genome has plummeted, and genomics has started to pervade health …
Clinical utility of genomic sequencing: a measurement toolkit
Whole-genome sequencing (WGS) is positioned to become one of the most robust
strategies for achieving timely diagnosis of rare genomic diseases. Despite its favorable …
strategies for achieving timely diagnosis of rare genomic diseases. Despite its favorable …
Clinical sequencing exploratory research consortium: accelerating evidence-based practice of genomic medicine
RC Green, KAB Goddard, GP Jarvik… - The American Journal of …, 2016 - cell.com
Despite rapid technical progress and demonstrable effectiveness for some types of
diagnosis and therapy, much remains to be learned about clinical genome and exome …
diagnosis and therapy, much remains to be learned about clinical genome and exome …
Perceived utility and disutility of genomic sequencing for pediatric patients: Perspectives from parents with diverse sociodemographic characteristics
Given the limited therapeutic options for most rare diseases diagnosed through genomic
sequencing (GS) and the proportion of patients who remain undiagnosed even after GS, it is …
sequencing (GS) and the proportion of patients who remain undiagnosed even after GS, it is …
Perceived utility of genomic sequencing: qualitative analysis and synthesis of a conceptual model to inform patient-centered instrument development
Abstract Background and Objectives Successful clinical integration of genomic sequencing
(GS) requires evidence of its utility. While GS potentially has benefits (utilities) or harms …
(GS) requires evidence of its utility. While GS potentially has benefits (utilities) or harms …
Defining personal utility in genomics: a Delphi study
JN Kohler, E Turbitt, KL Lewis, BS Wilfond… - Clinical …, 2017 - Wiley Online Library
Background Individual genome sequencing results are valued by patients in ways distinct
from clinical utility. Such outcomes have been described as components of “personal utility,” …
from clinical utility. Such outcomes have been described as components of “personal utility,” …
Utility of genetic testing from the perspective of parents/caregivers: a scoping review
RZ Hayeems, S Luca, D Assamad, A Bhatt, WJ Ungar - Children, 2021 - mdpi.com
In genomics, perceived and personal utility have been proposed as constructs of value that
include the subjective meanings and uses of genetic testing. Precisely what constitutes …
include the subjective meanings and uses of genetic testing. Precisely what constitutes …
Integrating precision cancer medicine into healthcare—policy, practice, and research challenges
Precision medicine (PM) can be defined as a predictive, preventive, personalized, and
participatory healthcare service delivery model. Recent developments in molecular biology …
participatory healthcare service delivery model. Recent developments in molecular biology …
Quality of life drives patients' preferences for secondary findings from genomic sequencing
C Mighton, L Carlsson, M Clausen… - European Journal of …, 2020 - nature.com
There is growing impetus to include measures of personal utility, the nonmedical value of
information, in addition to clinical utility in health technology assessment (HTA) of genomic …
information, in addition to clinical utility in health technology assessment (HTA) of genomic …