Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant
phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co …

Protein folding is a complex, error-prone process that often results in an irreparable protein
by-product. These by-products can be recognized by cellular quality control machineries …

Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

Phosphatidylcholine (PC) is the major phospholipid component of all plasma lipoprotein
classes. PC is the only phospholipid which is currently known to be required for lipoprotein …

Research into lipoprotein metabolism has developed because understanding lipoprotein
metabolism has important clinical indications. Lipoproteins are risk factors for cardiovascular …

Steady increase in the incidence of atherosclerosis is becoming a major concern not only in
the United States but also in other countries. One of the major risk factors for the …

Intracellular infectious hepatitis C virus (HCV) particles display a distinctly higher buoyant
density than do secreted virus particles, suggesting that the characteristic low density of …

The assembly of apolipoprotein B (apoB) into VLDL is broadly divided into two steps. The
first involves transfer of lipid by the microsomal triglyceride transfer protein (MTP) to apoB …

Apolipoprotein (apo) B circulates in two distinct forms, apoB100 and apoB48. Human liver
secretes apoB100, the product of a large mRNA encoding 4536 residues. The small …

Adipose differentiation-related protein (ADFP; also known as ADRP or adipophilin), is a lipid
droplet (LD) protein found in most cells and tissues. ADFP expression is strongly induced in …