Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …

In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …

Among all the stromal cells that present in the tumor microenvironment, cancer-associated
fibroblasts (CAFs) are one of the most abundant and critical components of the tumor …

Cancer-associated fibroblasts (CAFs) are prominent components of the microenvironment in
most types of solid tumors, and were shown to facilitate cancer progression by supporting …

The tumor microenvironment (TME) has been identified as one of the driving factors of tumor
progression and invasion. Within this microenvironment, cancer‐associated fibroblasts …

Abstract In tumors, Cancer-Associated Fibroblasts (CAFs) constitute the most prominent
component of the tumor microenvironment (TME). CAFs are heterogeneous and composed …

Cancer immunotherapies have rapidly changed the therapeutic landscape for cancer.
Nevertheless, most of the patients show innate or acquired resistance to these therapies …

Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment
(TME) with diverse functions such as extracellular matrix (ECM) remodeling, modulation of …

Fibroblast activation protein-α (FAP) is a type II integral serine protease that is specifically
expressed by activated fibroblasts. Cancer-associated fibroblasts (CAFs) in the tumor stroma …