Spina bifida
Spina bifida is a birth defect in which the vertebral column is open, often with spinal cord
involvement. The most clinically significant subtype is myelomeningocele (open spina …
involvement. The most clinically significant subtype is myelomeningocele (open spina …
Neural tube defects
NDE Greene, AJ Copp - Annual review of neuroscience, 2014 - annualreviews.org
Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth
defects of the central nervous system that originate during embryonic development when the …
defects of the central nervous system that originate during embryonic development when the …
Folic acid and primary prevention of neural tube defects: A review
JD van Gool, H Hirche, H Lax… - Reproductive …, 2018 - Elsevier
With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between
1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk. Therefore, folic …
1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk. Therefore, folic …
[HTML][HTML] Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development
N Padmanabhan, D Jia, C Geary-Joo, X Wu… - Cell, 2013 - cell.com
The importance of maternal folate consumption for normal development is well established,
yet the molecular mechanism linking folate metabolism to development remains poorly …
yet the molecular mechanism linking folate metabolism to development remains poorly …
A crucial role for maternal dietary methyl donor intake in epigenetic programming and fetal growth outcomes
M McGee, S Bainbridge, B Fontaine-Bisson - Nutrition reviews, 2018 - academic.oup.com
The fetal origins of health and disease framework has identified extremes in fetal growth and
birth weight as factors associated with the lifelong generation of chronic diseases such as …
birth weight as factors associated with the lifelong generation of chronic diseases such as …
Expression of folate transporters in human placenta and implications for homocysteine metabolism
N Solanky, AR Jimenez, SW D'Souza, CP Sibley… - Placenta, 2010 - Elsevier
Poor folate status during pregnancy can lead to elevated maternal plasma levels of
homocysteine (Hcy) with associated pregnancy complications and adverse neonatal …
homocysteine (Hcy) with associated pregnancy complications and adverse neonatal …
Homocysteine metabolism in pregnancy and developmental impacts
SW D'Souza, JD Glazier - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Homocysteine is a metabolite generated by methionine cycle metabolism, comprising the
demethylated derivative of methionine. Homocysteine can be metabolised by the …
demethylated derivative of methionine. Homocysteine can be metabolised by the …
MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild …
NM Jadavji, L Deng, O Malysheva, MA Caudill… - Neuroscience, 2015 - Elsevier
Genetic or nutritional disturbances in one-carbon metabolism, with associated
hyperhomocysteinemia, can result in complex disorders including pregnancy complications …
hyperhomocysteinemia, can result in complex disorders including pregnancy complications …
Methylenetetrahydrofolate reductase: biochemical characterization and medical significance
E E. Trimmer - Current pharmaceutical design, 2013 - benthamdirect.com
Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5, 10-
methylenetetrahydofolate (CH2-H4folate) to 5-methyltetrahydrofolate (CH3-H4folate). The …
methylenetetrahydofolate (CH2-H4folate) to 5-methyltetrahydrofolate (CH3-H4folate). The …
High intake of folic acid disrupts embryonic development in mice
BACKGROUND Folic acid fortification and supplementation has increased folate intake and
blood folate concentrations and successfully reduced the incidence of neural tube defects …
blood folate concentrations and successfully reduced the incidence of neural tube defects …