Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging
Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations,
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …
New frameworks for hematopoiesis derived from single-cell genomics
K Safina, P van Galen - Blood, 2024 - ashpublications.org
Recent advancements in single-cell genomics have enriched our understanding of
hematopoiesis, providing intricate details about hematopoietic stem cell biology …
hematopoiesis, providing intricate details about hematopoietic stem cell biology …
From Hematopoietic Stem Cells to Platelets: Unifying Differentiation Pathways Identified by Lineage Tracing Mouse Models
BA Manso, A Rodriguez y Baena, EC Forsberg - Cells, 2024 - mdpi.com
Platelets are the terminal progeny of megakaryocytes, primarily produced in the bone
marrow, and play critical roles in blood homeostasis, clotting, and wound healing …
marrow, and play critical roles in blood homeostasis, clotting, and wound healing …
Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging
Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSC) acquire mutations
in genes, including DNMT3A and TET2, conferring a competitive advantage through a …
in genes, including DNMT3A and TET2, conferring a competitive advantage through a …
An iron rheostat controls hematopoietic stem cell fate
Mechanisms governing the maintenance of blood-producing hematopoietic stem and
multipotent progenitor cells (HSPCs) are incompletely understood, particularly those …
multipotent progenitor cells (HSPCs) are incompletely understood, particularly those …
[HTML][HTML] Clonal hematopoiesis: role in hematologic and non-hematologic malignancies
U Testa, G Castelli, E Pelosi - Mediterranean Journal of …, 2022 - ncbi.nlm.nih.gov
Hematopoietic stem cells (HSCs) ensure the coordinated and balanced production of all
hematopoietic cell types throughout life. Aging is associated with a gradual decline of the …
hematopoietic cell types throughout life. Aging is associated with a gradual decline of the …