Entropy is a natural process that affects all living cells, including senescence, an irreversible
physiological process that impairs cell homeostasis. Age is a significant factor in disease …

It has long been thought that the functional identity of mammalian brain neurons is
programmed during development and remains stable throughout adult life; however, certain …

Aging-associated cardiac hypertrophy (AACH) increases susceptibility to heart failure in the
elderly. Chromatin remodeling contributes to the gene reprogramming in AACH; however …

Background Accelerated senescence of renal tubular epithelial cells (RTEC) is critical in the
progression of diabetic kidney disease (DKD). GLIS family zinc finger 1 (Glis1) alleviates …

Osteoarthritis (OA) is the most prevalent joint disorder occurring with articular cartilage
degradation, which includes a switch from an articular to a growth-plate chondrocyte …

The current state of biological knowledge contains an unresolved paradox: life as a
continuity in the face of the phenomena of ageing. In this manuscript I propose a theoretical …