Ribosome profiling: a powerful tool in oncological research
D Su, C Ding, J Qiu, G Yang, R Wang, Y Liu, J Tao… - Biomarker …, 2024 - Springer
Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing
or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an …
or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an …
[HTML][HTML] Targeting non-coding RNAs: Perspectives and challenges of in-silico approaches
R Rocca, K Grillone, EL Citriniti, G Gianmarco… - European Journal of …, 2023 - Elsevier
The growing information currently available on the central role of non-coding RNAs
(ncRNAs) including microRNAs (miRNAS) and long non-coding RNAs (lncRNAs) for chronic …
(ncRNAs) including microRNAs (miRNAS) and long non-coding RNAs (lncRNAs) for chronic …
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation.
Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively …
Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively …
CRISPR–Cas9-based functional interrogation of unconventional translatome reveals human cancer dependency on cryptic non-canonical open reading frames
Emerging evidence suggests that cryptic translation beyond the annotated translatome
produces proteins with developmental or physiological functions. However, functions of …
produces proteins with developmental or physiological functions. However, functions of …
Widespread stable noncanonical peptides identified by integrated analyses of ribosome profiling and ORF features
Studies have revealed dozens of functional peptides in putative 'noncoding'regions and
raised the question of how many proteins are encoded by noncanonical open reading …
raised the question of how many proteins are encoded by noncanonical open reading …
Translational adaptation in breast cancer metastasis and emerging therapeutic opportunities
Breast cancer's tendency to metastasize poses a critical barrier to effective treatment,
making it a leading cause of mortality among women worldwide. A growing body of …
making it a leading cause of mortality among women worldwide. A growing body of …
The neoantigens derived from transposable elements–A hidden treasure for cancer immunotherapy
Z Hu, X Guo, Z Li, Z Meng, S Huang - … et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Neoantigen-based therapy is a promising approach that selectively activates the immune
system of the host to recognize and eradicate cancer cells. Preliminary clinical trials have …
system of the host to recognize and eradicate cancer cells. Preliminary clinical trials have …
Noncanonical microprotein regulation of immunity
C Nichols, DC Peltier - Molecular Therapy, 2024 - cell.com
The immune system is highly regulated but, when dysregulated, suboptimal protective or
overly robust immune responses can lead to immune-mediated disorders. The genetic and …
overly robust immune responses can lead to immune-mediated disorders. The genetic and …
Upstream open reading frames: new players in the landscape of cancer gene regulation
A Dasgupta, JR Prensner - NAR cancer, 2024 - academic.oup.com
The translation of RNA by ribosomes represents a central biological process and one of the
most dysregulated processes in cancer. While translation is traditionally thought to occur …
most dysregulated processes in cancer. While translation is traditionally thought to occur …
The Non-Coding RNA Journal Club: Highlights on Recent Papers—12
We are delighted to share with you our twelfth Journal Club and highlight some of the most
interesting papers published recently. We hope to keep you up-to-date with non-coding RNA …
interesting papers published recently. We hope to keep you up-to-date with non-coding RNA …