Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing
or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an …

The growing information currently available on the central role of non-coding RNAs
(ncRNAs) including microRNAs (miRNAS) and long non-coding RNAs (lncRNAs) for chronic …

A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation.
Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively …

Emerging evidence suggests that cryptic translation beyond the annotated translatome
produces proteins with developmental or physiological functions. However, functions of …

Studies have revealed dozens of functional peptides in putative 'noncoding'regions and
raised the question of how many proteins are encoded by noncanonical open reading …

Breast cancer's tendency to metastasize poses a critical barrier to effective treatment,
making it a leading cause of mortality among women worldwide. A growing body of …

Neoantigen-based therapy is a promising approach that selectively activates the immune
system of the host to recognize and eradicate cancer cells. Preliminary clinical trials have …

The immune system is highly regulated but, when dysregulated, suboptimal protective or
overly robust immune responses can lead to immune-mediated disorders. The genetic and …

The translation of RNA by ribosomes represents a central biological process and one of the
most dysregulated processes in cancer. While translation is traditionally thought to occur …

We are delighted to share with you our twelfth Journal Club and highlight some of the most
interesting papers published recently. We hope to keep you up-to-date with non-coding RNA …