Bile acid toxicity structure–activity relationships: correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell …
R Sharma, F Majer, VK Peta, J Wang… - Bioorganic & medicinal …, 2010 - Elsevier
The molecular mechanisms and interactions underlying bile acid cytotoxicity are important to
understand for intestinal and hepatic disease treatment and prevention and the design of …
understand for intestinal and hepatic disease treatment and prevention and the design of …
Bile acid metabolomics identifies chenodeoxycholic acid as a therapeutic agent for pancreatic necrosis
Q Zhu, C Yuan, X Dong, Y Wang, B Li, B Tu… - Cell Reports …, 2023 - cell.com
Bile acids are altered and associated with prognosis in patients with acute pancreatitis (AP).
Here, we conduct targeted metabolomic analyses to detect bile acids changes in patients …
Here, we conduct targeted metabolomic analyses to detect bile acids changes in patients …
Determination of number-average aggregation numbers of bile salts micelles with a special emphasis on their oxo derivatives—The effect of the steroid skeleton
M Poša, A Sebenji - Biochimica et Biophysica Acta (BBA)-General Subjects, 2014 - Elsevier
Background The special geometry of the steroid skeleton causes that bile acid anions, in
contrast to aliphatic amphiphiles, form micelles with a small aggregation number. Methods …
contrast to aliphatic amphiphiles, form micelles with a small aggregation number. Methods …
[HTML][HTML] Novel steroid derivatives: synthesis, antileishmanial activity, mechanism of action, and in silico physicochemical and pharmacokinetics studies
J da Trindade Granato, JA Dos Santos… - Biomedicine & …, 2018 - Elsevier
The search for new drugs for the treatment of leishmaniasis is an important strategy for
improving the current therapeutic arsenal for the disease. There are several limitations to the …
improving the current therapeutic arsenal for the disease. There are several limitations to the …
Mixed micelles of sodium salts of bile acids and Tween 40: effect of the steroid skeleton on the coefficient of interaction in mixed micelles
Salts of bile acids are steroid amphiphilic compounds which form micelles consisting of 2–
12 monomer units. In nature, the formation of mixed micelles with phospholipids (gall …
12 monomer units. In nature, the formation of mixed micelles with phospholipids (gall …
Synthesis of 5α-cholestan-6-one derivatives and their inhibitory activities of NO production in activated microglia: Discovery of a novel neuroinflammation inhibitor
YX Yang, LT Zheng, JJ Shi, B Gao, YK Chen… - Bioorganic & medicinal …, 2014 - Elsevier
Glial activation-mediated neuroinflammation plays a pivotal role in the process of several
neuroinflammatory diseases including stroke, Alzheimer's diseases, Parkinson's diseases …
neuroinflammatory diseases including stroke, Alzheimer's diseases, Parkinson's diseases …
Molecular interactions between selected sodium salts of bile acids and morphine hydrochloride
The objective of this study was to understand the prolonged analgesic action of morphine
hydrochloride observed in the presence of sodium 12-oxochenodeoxycholanate. Based on …
hydrochloride observed in the presence of sodium 12-oxochenodeoxycholanate. Based on …
QSPR study of the effect of steroidal hydroxy and oxo substituents on the critical micellar concentration of bile acids
M Poša - Steroids, 2011 - Elsevier
Measurements of the fluorescence intensity of 1, 6-diphenylhexatriene (DPH) as a probe
molecule allowed the determination of critical micellar concentrations (CMCs) for 30 bile …
molecule allowed the determination of critical micellar concentrations (CMCs) for 30 bile …
Retention data of bile acids and their oxo derivatives in characterization of pharmacokinetic properties and in silico ADME modeling
J Trifunović, V Borčić, S Vukmirović, SG Kon… - European Journal of …, 2016 - Elsevier
Purpose Information on ADME properties of examined bile acids and their oxo derivatives
are scarce, although the interest for bile acids and their use in nanochemistry and …
are scarce, although the interest for bile acids and their use in nanochemistry and …
Hydrophobicity and Self-association of Bile Acids with a Special Emphasis on oxo Derivatives of 5-β Cholanic Acid
M Posa - Current Organic Chemistry, 2012 - ingentaconnect.com
The article is an extensive review of the influence of the structure of bile acids on their
hydrophobicity as expressed via the retention parameters of reverse phase chromatography …
hydrophobicity as expressed via the retention parameters of reverse phase chromatography …