Organismal aging is often characterized as a steady, monotonic decline of organ and tissue
function. However, recent studies indicate spatial and temporal variations of aging rates …

ABSTRACT A major challenge in the biology of aging is to understand how specific age-
onset pathologies relate to the overall health of the organism. The integrity of the intestinal …

Aging's most obvious characteristic is the time dependent increase of an individual's
probability to die. This lifelong process is accompanied by a large number of molecular and …

Abstract The Smurf Assay (SA) was initially developed in the model organism Drosophila
melanogaster where a dramatic increase of intestinal permeability has been shown to occur …

Intestinal barrier dysfunction is hypothesized to be a contributing determinant of two
prominent characteristics of aging: inflammation and decline in physical function. A …

Increased intestinal barrier permeability has been correlated with aging and disease,
including type 2 diabetes, Crohn's disease, celiac disease, multiple sclerosis and irritable …

Parameters correlated with age and mortality in Drosophila melanogaster include
decreased negative geotaxis and centrophobism behaviors, decreased climbing and …

In recent years, reports of non-linear regulations in age-and longevity-associated biological
processes have been accumulating. Inspired by methodological advances in precision …

The gut barrier separates trillions of microbes from the largest immune system in the body;
when compromised, a “leaky” gut barrier fuels systemic inflammation, which hastens the …

Although DNA methylation data yields highly accurate age predictors, little is known about
the dynamics of this quintessential epigenomic biomarker during lifespan. To narrow the …