Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

RD Klein, SJ Hultgren - Nature Reviews Microbiology, 2020 - nature.com
Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …

Advances in understanding the human urinary microbiome and its potential role in urinary tract infection

ML Neugent, NV Hulyalkar, VH Nguyen, PE Zimmern… - MBio, 2020 - Am Soc Microbiol
Recent advances in the analysis of microbial communities colonizing the human body have
identified a resident microbial community in the human urinary tract (UT). Compared to many …

Recurrent urinary tract infection: a mystery in search of better model systems

BO Murray, C Flores, C Williams… - Frontiers in cellular …, 2021 - frontiersin.org
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …

A human urothelial microtissue model reveals shared colonization and survival strategies between uropathogens and commensals

C Flores, J Ling, A Loh, RG Maset, A Aw, IJ White… - Science …, 2023 - science.org
Urinary tract infection is among the most common infections worldwide, typically studied in
animals and cell lines with limited uropathogenic strains. Here, we assessed diverse …

[HTML][HTML] The urinary microbiome and biological therapeutics: Novel therapies for urinary tract infections

C Kenneally, CP Murphy, RD Sleator… - Microbiological …, 2022 - Elsevier
The discovery of microbial communities in the urinary tract (the urobiome) has fundamentally
altered the previous doctrine regarding urine sterility and associated urinary disorders …

[HTML][HTML] The microbiome and host mucosal interactions in urinary tract diseases

B Jones-Freeman, M Chonwerawong, VR Marcelino… - Mucosal …, 2021 - Elsevier
The urinary tract consists of the bladder, ureters, and kidneys, and is an essential organ
system for filtration and excretion of waste products and maintaining systemic homeostasis …

Rapid growth and metabolism of uropathogenic Escherichia coli in relation to urine composition

L Reitzer, P Zimmern - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Uropathogenic Escherichia coli (UPEC) strains cause a majority of urinary tract infections
(UTIs). Since UPEC strains can become antibiotic resistant, adjunct or alternate therapies …

Effects of aging on urinary tract epithelial homeostasis and immunity

MM Ligon, CS Joshi, BE Fashemi, AM Salazar… - Developmental …, 2023 - Elsevier
A global increase in older individuals creates an increasing demand to understand
numerous healthcare challenges related to aging. This population is subject to changes in …

Recurrent urinary tract infection and estrogen shape the taxonomic ecology and function of the postmenopausal urogenital microbiome

ML Neugent, A Kumar, NV Hulyalkar, KC Lutz… - Cell Reports …, 2022 - cell.com
Postmenopausal women are severely affected by recurrent urinary tract infection (rUTI). The
urogenital microbiome is a key component of the urinary environment. However, changes in …

Gut-bladder axis enters the stage: Implication for recurrent urinary tract infections

AM Salazar, ML Neugent, NJ De Nisco, IU Mysorekar - Cell host & microbe, 2022 - cell.com
The gut microbiome is a critical modulator of systemic physiology, including infectious
disease susceptibility. Although this niche is a reservoir for uropathogenic Escherichia coli …