Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies
RD Klein, SJ Hultgren - Nature Reviews Microbiology, 2020 - nature.com
Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …
threatening. The continued emergence of antibiotic resistance, together with our increasing …
Advances in understanding the human urinary microbiome and its potential role in urinary tract infection
Recent advances in the analysis of microbial communities colonizing the human body have
identified a resident microbial community in the human urinary tract (UT). Compared to many …
identified a resident microbial community in the human urinary tract (UT). Compared to many …
Recurrent urinary tract infection: a mystery in search of better model systems
BO Murray, C Flores, C Williams… - Frontiers in cellular …, 2021 - frontiersin.org
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …
A human urothelial microtissue model reveals shared colonization and survival strategies between uropathogens and commensals
Urinary tract infection is among the most common infections worldwide, typically studied in
animals and cell lines with limited uropathogenic strains. Here, we assessed diverse …
animals and cell lines with limited uropathogenic strains. Here, we assessed diverse …
[HTML][HTML] The urinary microbiome and biological therapeutics: Novel therapies for urinary tract infections
The discovery of microbial communities in the urinary tract (the urobiome) has fundamentally
altered the previous doctrine regarding urine sterility and associated urinary disorders …
altered the previous doctrine regarding urine sterility and associated urinary disorders …
[HTML][HTML] The microbiome and host mucosal interactions in urinary tract diseases
The urinary tract consists of the bladder, ureters, and kidneys, and is an essential organ
system for filtration and excretion of waste products and maintaining systemic homeostasis …
system for filtration and excretion of waste products and maintaining systemic homeostasis …
Rapid growth and metabolism of uropathogenic Escherichia coli in relation to urine composition
L Reitzer, P Zimmern - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Uropathogenic Escherichia coli (UPEC) strains cause a majority of urinary tract infections
(UTIs). Since UPEC strains can become antibiotic resistant, adjunct or alternate therapies …
(UTIs). Since UPEC strains can become antibiotic resistant, adjunct or alternate therapies …
Effects of aging on urinary tract epithelial homeostasis and immunity
MM Ligon, CS Joshi, BE Fashemi, AM Salazar… - Developmental …, 2023 - Elsevier
A global increase in older individuals creates an increasing demand to understand
numerous healthcare challenges related to aging. This population is subject to changes in …
numerous healthcare challenges related to aging. This population is subject to changes in …
Recurrent urinary tract infection and estrogen shape the taxonomic ecology and function of the postmenopausal urogenital microbiome
Postmenopausal women are severely affected by recurrent urinary tract infection (rUTI). The
urogenital microbiome is a key component of the urinary environment. However, changes in …
urogenital microbiome is a key component of the urinary environment. However, changes in …
Gut-bladder axis enters the stage: Implication for recurrent urinary tract infections
The gut microbiome is a critical modulator of systemic physiology, including infectious
disease susceptibility. Although this niche is a reservoir for uropathogenic Escherichia coli …
disease susceptibility. Although this niche is a reservoir for uropathogenic Escherichia coli …