Hereditary hemochromatosis (HH) is a genetic disease leading to excessive iron absorption,
its accumulation, and oxidative stress induction causing different organ damage, including …

Background The clinical application of cardiovascular magnetic resonance (CMR) T 2 and T
2* mapping is currently limited as ranges for healthy and cardiac diseases are poorly …

The use of MRI for the assessment of iron overload in thalassemia began its rapidly
increasing use after the seminal work by Anderson and colleagues 1 in 2001. With an …

Background Hereditary hemochromatosis (HH) is a genetic disease that leads to increased
iron accumulation in several organs. Cardiomyocytes are highly susceptible to this damage …

Objective Myocardial iron overload (MIO) in thalassemia major (TM) may cause subclinical
left ventricular (LV) dysfunction which manifests with abnormal strain parameters before a …

Heart disease is among the primary causes of morbidity and mortality in β-thalassemia
major (β-TM). Conventional echocardiography has failed to identify myocardial dysfunction …

Background Hereditary haemochromatosis (HH) is a common inherited disease. Abnormally
increased intestinal iron absorption and accelerated recycling of iron by macrophages lead …

Thalassemia syndromes are complex systemic disorders. Clinical complications are related
to the underlying pathophysiological mechanisms, namely ineffective erythropoiesis, chronic …

Speckle-tracking echocardiography has enabled clinicians to detect changes in myocardial
function with more sensitivity than that afforded by traditional diastolic and systolic functional …

Cardiovascular disease (CVD) has been showing patterns of extensive rise in prevalence in
the contemporary era, affecting the quality of life of millions of people and leading the …