The aging navigational system

AW Lester, SD Moffat, JM Wiener, CA Barnes… - Neuron, 2017 - cell.com
The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …

Integrating new findings and examining clinical applications of pattern separation

SL Leal, MA Yassa - Nature neuroscience, 2018 - nature.com
Pattern separation, the ability to independently represent and store similar experiences, is a
crucial facet of episodic memory. Growing evidence suggests that the hippocampus …

The human dentate gyrus plays a necessary role in discriminating new memories

S Baker, P Vieweg, F Gao, A Gilboa, T Wolbers… - Current Biology, 2016 - cell.com
Our day-to-day experiences are often similar to one another, occurring in the same place at
the same time of day, with common people and objects, and with a shared purpose. Humans …

[HTML][HTML] Age-related functional changes in domain-specific medial temporal lobe pathways

D Berron, K Neumann, A Maass, H Schütze… - Neurobiology of …, 2018 - Elsevier
There is now converging evidence from studies in animals and humans that the medial
temporal lobes (MTLs) harbor anatomically distinct processing pathways for object and …

Memory reactivation during learning simultaneously promotes dentate gyrus/CA2, 3 pattern differentiation and CA1 memory integration

RJ Molitor, KR Sherrill, NW Morton… - Journal of …, 2021 - Soc Neuroscience
Events that overlap with previous experience may trigger reactivation of existing memories.
However, such reactivation may have different representational consequences within the …

Ageing-and dementia-friendly design: theory and evidence from cognitive psychology, neuropsychology and environmental psychology can contribute to design …

JM Wiener, F Pazzaglia - Cognitive processing, 2021 - Springer
Many older people, both with and without dementia, eventually move from their familiar
home environments into unfamiliar surroundings, such as sheltered housing or care homes …

Eye movements support behavioral pattern completion

JS Wynn, JD Ryan… - Proceedings of the …, 2020 - National Acad Sciences
The ability to recall a detailed event from a simple reminder is supported by pattern
completion, a cognitive operation performed by the hippocampus wherein existing …

Development of holistic episodic recollection

CT Ngo, AJ Horner, NS Newcombe… - Psychological …, 2019 - journals.sagepub.com
Episodic memory binds the diverse elements of an event into a coherent representation.
This coherence allows for the reconstruction of different aspects of an experience when …

Tests of pattern separation and pattern completion in humans—A systematic review

KY Liu, RL Gould, MC Coulson, EV Ward… - …, 2016 - Wiley Online Library
To systematically review the characteristics, validity and outcome measures of tasks that
have been described in the literature as assessing pattern separation and pattern …

Pattern separation and pattern completion: Behaviorally separable processes?

CT Ngo, S Michelmann, IR Olson, NS Newcombe - Memory & Cognition, 2021 - Springer
Episodic memory capacity requires several processes, including mnemonic discrimination of
similar experiences, termed pattern separation, and holistic retrieval of multidimensional …