[HTML][HTML] The glycocalyx: a novel diagnostic and therapeutic target in sepsis
R Uchimido, EP Schmidt, NI Shapiro - Critical care, 2019 - Springer
The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It
is comprised of membrane-attached proteoglycans, glycosaminoglycan chains …
is comprised of membrane-attached proteoglycans, glycosaminoglycan chains …
[HTML][HTML] Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of …
In hormone-dependent breast cancer, estrogen receptors are the principal signaling
molecules that regulate several cell functions either by the genomic pathway acting directly …
molecules that regulate several cell functions either by the genomic pathway acting directly …
[HTML][HTML] The prediction of early preeclampsia: Results from a longitudinal proteomics study
Objectives To identify maternal plasma protein markers for early preeclampsia (delivery< 34
weeks of gestation) and to determine whether the prediction performance is affected by …
weeks of gestation) and to determine whether the prediction performance is affected by …
[HTML][HTML] Endothelial glycocalyx degradation in critical illness and injury
The endothelial glycocalyx is a gel-like layer on the luminal side of blood vessels that is
composed of glycosaminoglycans and the proteins that tether them to the plasma …
composed of glycosaminoglycans and the proteins that tether them to the plasma …
[HTML][HTML] Collagen assembly at the cell surface: dogmas revisited
With the increased awareness about the importance of the composition, organization, and
stiffness of the extracellular matrix (ECM) for tissue homeostasis, there is a renewed need to …
stiffness of the extracellular matrix (ECM) for tissue homeostasis, there is a renewed need to …
[HTML][HTML] The endothelial glycocalyx as a double-edged sword in microvascular homeostasis and pathogenesis
N Villalba, S Baby, SY Yuan - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Expressed on the endothelial cell (EC) surface of blood vessels, the glycocalyx (GCX), a
mixture of carbohydrates attached to proteins, regulates the access of cells and molecules in …
mixture of carbohydrates attached to proteins, regulates the access of cells and molecules in …
[HTML][HTML] Syndecans in inflammation at a glance
S Gopal - Frontiers in immunology, 2020 - frontiersin.org
Syndecans are transmembrane proteoglycans with heparan and chondroitin sulfate chains
attached to their extracellular domain. Like many proteoglycans, they interact with a large …
attached to their extracellular domain. Like many proteoglycans, they interact with a large …
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine
Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …
[HTML][HTML] Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7
Y Xiao, H Lian, XS Zhong… - Frontiers in …, 2022 - frontiersin.org
Background Previous studies implicated matrix metalloproteinases (MMPs), such as MMP-7,
in inflammatory bowel diseases (IBD) by showing increased activity during inflammation of …
in inflammatory bowel diseases (IBD) by showing increased activity during inflammation of …
[HTML][HTML] Endothelial glycocalyx degradation during sepsis: Causes and consequences
RC Sullivan, MD Rockstrom, EP Schmidt… - Matrix Biology Plus, 2021 - Elsevier
The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the
vascular lumen. It is enriched in proteoglycans, which are proteins attached to the …
vascular lumen. It is enriched in proteoglycans, which are proteins attached to the …