The dominant hypothesis of Alzheimer's disease (AD) aetiology, the neuropathological
guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both …

Alzheimer's Disease (AD) therapeutics based on the amyloid hypothesis have repeatedly
failed in clinical trials. Together with numerous reports that amyloid is present in brains from …

In this article, we examine how symptoms are conceptualized in theories of
psychopathology. We identify five questions that need to be asked about symptoms …

Abstract Background Alzheimer's Disease (AD) is a complex and multifactorial disease and
novel approaches are needed to illuminate the underlying pathology. Metabolites comprise …

Advances in human genetics raise many social and ethical issues. The application of
genomic technologies to healthcare has raised many questions at the level of the individual …

Theory of illness causation is an important issue in all biomedical sciences, and solid
etiological explanations are needed in order to develop therapeutic approaches in medicine …

Background From a public health perspective, a healthier community environment correlates
with fewer occurrences of chronic or infectious diseases. Our premise is that community …

Occupational hazards and obesity can lead to extensive morbidity and mortality and put
great financial burden on society. Historically, occupational hazards and obesity have been …

The goal of this paper is two-fold: first, to emphasize causality in disease ontology and
knowledge representation, presenting a general and cursory discussion of causality and …

Identifying biomarkers for Alzheimer's disease (AD) is crucial, due to its complex pathology,
which involves dysfunction in lipid transport, contributing to neuroinflammation, synaptic …