Current drugs for HIV-1: from challenges to potential in HIV/AIDS
Y Peng, Y Zong, D Wang, J Chen, ZS Chen… - Frontiers in …, 2023 - frontiersin.org
The human immunodeficiency virus (HIV) persists in latently infected CD4+ T cells and
integrates with the host genome until cell death. Acquired immunodeficiency syndrome …
integrates with the host genome until cell death. Acquired immunodeficiency syndrome …
Stabilized trimeric peptide immunogens of the complete HIV-1 gp41 N-heptad repeat and their use as HIV-1 vaccine candidates
C Wu, IT Raheem, DD Nahas… - Proceedings of the …, 2024 - National Acad Sciences
Efforts to develop an HIV-1 vaccine include those focusing on conserved structural elements
as the target of broadly neutralizing monoclonal antibodies. MAb D5 binds to a highly …
as the target of broadly neutralizing monoclonal antibodies. MAb D5 binds to a highly …
Identification of a conserved neutralizing epitope present on spike proteins from all highly pathogenic coronaviruses
Three pathogenic human coronaviruses have emerged, with SARS-CoV-2 causing a global
pandemic. While therapeutic antibodies targeting the SARS-2 spike currently focus on the …
pandemic. While therapeutic antibodies targeting the SARS-2 spike currently focus on the …
HIV-1 prehairpin intermediate inhibitors show efficacy independent of neutralization tier
BN Bell, TUJ Bruun, N Friedland… - Proceedings of the …, 2023 - National Acad Sciences
HIV-1 strains are categorized into one of three neutralization tiers based on the relative ease
by which they are neutralized by plasma from HIV-1–infected donors not on antiretroviral …
by which they are neutralized by plasma from HIV-1–infected donors not on antiretroviral …
Enhancing HIV-1 Neutralization by Increasing the Local Concentration of Membrane-Proximal External Region-Directed Broadly Neutralizing Antibodies
Broadly neutralizing antibodies (bNAbs) against the membrane-proximal external region
(MPER) of the gp41 component of the human immunodeficiency virus type 1 (HIV-1) …
(MPER) of the gp41 component of the human immunodeficiency virus type 1 (HIV-1) …
A dePEGylated Lipopeptide-Based Pan-Coronavirus Fusion Inhibitor Exhibits Potent and Broad-Spectrum Anti-HIV-1 Activity without Eliciting Anti-PEG Antibodies
L Xu, C Wang, W Xu, L Xing, J Zhou, J Pu, M Fu… - International Journal of …, 2023 - mdpi.com
We previously identified a lipopeptide, EK1C4, by linking cholesterol to EK1, a pan-CoV
fusion inhibitory peptide via a polyethylene glycol (PEG) linker, which showed potent pan …
fusion inhibitory peptide via a polyethylene glycol (PEG) linker, which showed potent pan …
HIV-1 neutralization tiers are not relevant for inhibitors targeting the pre-hairpin intermediate
HIV-1 strains are categorized into one of three neutralization tiers based on the relative ease
by which they are neutralized by plasma from HIV-1 infected donors not on antiretroviral …
by which they are neutralized by plasma from HIV-1 infected donors not on antiretroviral …
A new lease on life for an HIV-neutralizing antibody class and vaccine target
DR Burton - Proceedings of the National Academy of …, 2021 - National Acad Sciences
Neutralizing antibodies (nAbs), in the time of COVID-19, have received much attention in the
lay press owing to their association with vaccine protection against severe acute respiratory …
lay press owing to their association with vaccine protection against severe acute respiratory …
Enhancing HIV-1 neutralization by increasing the local concentration of MPER-directed bnAbs
S Kim, MVF Interrante, PS Kim - bioRxiv, 2022 - biorxiv.org
Broadly neutralizing antibodies (bnAbs) against the membrane-proximal external region
(MPER) of the gp41 component of the HIV-1 envelope (Env) are characterized by long …
(MPER) of the gp41 component of the HIV-1 envelope (Env) are characterized by long …
Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies
The hydrophobic pocket found in the N-heptad repeat (NHR) region of HIV-1 gp41 is a
highly conserved epitope that is the target of various HIV-1-neutralizing monoclonal …
highly conserved epitope that is the target of various HIV-1-neutralizing monoclonal …