Significance: Hypoxia is emerging as a crucial regulator of the tumor microenvironment; it
governs the metastatic potential of multiple primary cancers. It is also potentially involved in …

Cells use their cytoskeletons to move, polarise, divide and maintain organisation within
multicellular tissues. Actin is a highly conserved essential building block of the cytoskeleton …

A confluence of recent observations has indicted the Ras-family G-proteins RALA and RALB
as key offenders in the subversion of core biological systems driving oncogenic …

Abstract The Ras-like GTPases RalA and RalB are important drivers of tumour growth and
metastasis. Chemicals that block Ral function would be valuable as research tools and for …

More than a hundred proteins comprise the RAS superfamily of small GTPases. This family
can be divided into RAS, RHO, RAB, RAN, ARF, and RAD subfamilies, with each shown to …

Hypoxia drives malignant progression in part by promoting accumulation of the oncogenic
transcription factor hypoxia inducible factor–1α (HIF-1α) in tumor cells. Tumor …

Cell migration is essential to cancer invasion and metastasis and is spatially and temporally
integrated through transcriptionally dependent and independent mechanisms. As cell …

The connection between cancer and inflammation is widely recognized, yet the underlying
molecular mechanisms are poorly understood. We report here that TIPE2 provides a …

Since their discovery in 1986, Ral (Ras-like) GTPases have emerged as critical regulators of
diverse cellular functions. Ral-selective guanine nucleotide exchange factors (RalGEFs) …

The high frequency of RAS mutations in human cancers (33%) has stimulated intense
interest in the development of anti-Ras inhibitors for cancer therapy. Currently, the major …