Primary prevention through lifestyle interventions is a cost-effective alternative for preventing
a large burden of chronic and degenerative diseases, including cancer, which is one of the …

Significance: Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous
antioxidant defenses maintaining the steady-state levels of O2·−; no wonder, thus, that their …

Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal
physiological conditions, ROS production is tightly regulated, and ROS participate in both …

Radiotherapy is one of the most efficient ways to treat cancer. However, deleterious effects,
such as acute and chronic toxicities that reduce the quality of life, may result. Naturally …

Radioprotectors are compounds that protect against radiation injury when given prior to
radiation exposure. Mitigators can protect against radiation injury when given after exposure …

Normal tissue injury from irradiation is an unfortunate consequence of radiotherapy.
Technologic improvements have reduced the risk of normal tissue injury; however, toxicity …

The resistance to therapy of cancer cells is a challenge for achieving an appropriate
therapeutic outcome. Cancer (stem) cells possess several mechanisms for increasing their …

Purpose: The threat of a radiological/nuclear event is a critical concern for all government
agencies involved in national security and public health preparedness. Countermeasures …

Aims: Radiation-induced normal tissue toxicity is closely linked to endothelial cell (EC)
damage and dysfunction (acute effects). However, the underlying mechanisms of radiation …

Normal tissue damages induced by radiation therapy remain dose-limiting factors in
radiation oncology and this is still true despite recent advances in treatment planning and …