Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are
the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in …

The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of
metabolism, stress resistance and longevity. Apart from its role as an important redox carrier …

This review focuses on molecular, cellular, and functional changes that occur in the
vasculature during aging; explores the links between mitochondrial oxidative stress …

Aging is associated with the accumulation of cellular damage over the course of a lifetime.
This process is promoted in large part by reactive oxygen species (ROS) generated via …

Aging is an important risk factor for the development of many cardiovascular diseases as
atherosclerosis and hypertension with a common underlying circumstance: the progressive …

Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …

Aging-induced pathological alterations of the circulatory system play a critical role in
morbidity and mortality of older adults. While the importance of cellular and molecular …

Parthanatos is a cell death signaling pathway in which excessive oxidative damage to DNA
leads to over-activation of poly (ADP-ribose) polymerase (PARP). PARP then generates the …