Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …

Malignant pleural mesothelioma (MPM) is a highly invasive form of lung cancer that
adversely affects the pleural and other linings of the lungs. MPM is a very aggressive tumor …

Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine
kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug …

Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which
contributes to drug resistance, necessitating development of novel therapeutic approaches …

Kinase inhibitor research is a comparatively recent branch of medicinal chemistry and
pharmacology and the first small‐molecule kinase inhibitor, imatinib, was approved for …

Simple Summary Chronic lymphocytic leukemia represents the most frequent leukemia in
adults and evolves from an indolent phase to an aggressive lymphoma in 5–10% of the …

The serine/threonine-specific Moloney murine leukemia virus (PIM) kinase family (ie, PIM1,
PIM2, and PIM3) has been extensively studied in tumorigenesis. PIM kinases are …

The PIM Kinases belong to the family of a proto-oncogene that essentially phosphorylates
the serine/threonine residues of the target proteins. They are primarily categorized into three …

Background PIM kinases are well-studied drug targets for cancer, belonging to
Serine/Threonine kinases family. They are the downstream target of various signaling …

The adaptor protein TNF receptor-associated factor 3 (TRAF3) serves as a powerful
negative regulator in multiple aspects of B cell biology. Early in vitro studies in transformed …