Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Lack of immune system cells or impairment in differentiation of immune cells is the basis for
many chronic diseases. Metabolic changes could be the root cause for this immune cell …

Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant
mitochondria. Accumulating evidence implicates elimination of dysfunctional mitochondria …

Background Patients with systemic lupus erythematosus have T-cell dysfunction that has
been attributed to the activation of the mammalian target of rapamycin (mTOR). Rapamycin …

The last decade has been marked by tremendous progress in our understanding of the cell
biology of mitochondria, with the identification of molecules and mechanisms that regulate …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Background and aims Defective autophagy has been proposed as an important event in a
growing number of autoimmune and inflammatory diseases such as rheumatoid arthritis and …

Objectives The release of neutrophil extracellular traps (NETs) represents a novel neutrophil
effector function in systemic lupus erythematosus (SLE) pathogenesis. However, the …

Mechanistic target of rapamycin (mTOR, also known as mammalian target of rapamycin) is a
ubiquitous serine/threonine kinase that regulates cell growth, proliferation and survival …