Abstract Phosphoinositide-specific phospholipase Cs (PLCs) are expressed in all
mammalian cells and play critical roles in signal transduction. To obtain a comprehensive …

Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen
different family members have been cloned. These family members have unique structures …

Phosphoinositides (PI) form just a minor portion of the total phospholipid content in cells but
are significantly involved in cancer development and progression. In several cancer types …

Introduction Brain metastasis is a highly traumatic event in the progression of malignant
tumors, often symbolizing higher mortality. Metabolic alterations are hallmarks of cancer …

Glioblastoma represents the most lethal brain tumor in adults. Several studies have shown
the key role of phospholipase C β1 (PLCβ1) in the regulation of many mechanisms within …

Fat deposition in pigs is not only closely related to pig production efficiency and pork quality
but also an ideal model for human obesity. Transcriptome sequencing is widely used to …

Phosphoinositide-specific phospholipases C (PI-PLCs) are a class of enzymes involved in
the phosphatidylinositol metabolism, which is implicated in the activation of several …

Phosphoinositide-specific phospholipases C (PI-PLCs) are involved in signaling pathways
related to critical cellular functions, such as cell cycle regulation, cell differentiation, and …

Phosphatidylinositols (PIs) are responsible for several signaling pathways related to many
cellular functions, such as cell cycle regulation at different check-points, cell proliferation …

The mechanisms that maintain genome stability are critical for preventing tumor progression.
In the past decades, many strategies were developed for cancer treatment to disrupt the …