Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Fat cell metabolism has an impact on body homeostasis and its proper function.
Nevertheless, the knowledge about simultaneous metabolic processes, which occur during …

White adipose tissue browning is a key metabolic process controlled by epigenetic factors
that facilitate changes in gene expression leading to altered cell identity. We find that male …

Summary Down syndrome (DS, trisomy 21) is associated with developmental abnormalities
and increased leukemia risk. To reconcile chromatin alterations with transcriptome changes …

Multiple transcriptional and epigenetic changes drive differentiation of embryonic stem cells
(ESCs). This study unveils an additional level of gene expression regulation involving …

Cell cycle exit is an obligatory step for the differentiation of oligodendrocyte progenitor cells
(OPCs) into myelinating cells. A key regulator of the transition from proliferation to …

Chromatin plays a key role in regulating gene expression programs necessary for the
orderly progress of development and for preventing changes in cell identity that can lead to …

Mutations in Peroxidasin (PXDN) cause severe inherited eye disorders in humans, such as
congenital cataract, corneal opacity and developmental glaucoma. The role of peroxidasin …

The dynamic nature of the chromatin epigenetic landscape plays a key role in the
establishment and maintenance of cell identity, yet the factors that affect the dynamics of the …

The DNA replication program is, in part, determined by the epigenetic landscape that
governs local chromosome architecture and directs chromosome duplication. Replication …