The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

X He, Y Li, B Deng, A Lin, G Zhang, M Ma… - Cell …, 2022 - Wiley Online Library
Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

Inflammation: a target for treatment in spinal cord injury

X Freyermuth-Trujillo, JJ Segura-Uribe… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

Pathophysiology and therapeutic approaches for spinal cord injury

R Lima, A Monteiro, AJ Salgado, S Monteiro… - International Journal of …, 2022 - mdpi.com
Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic
functions. Despite extensive research in the last decades, SCI continues to be a global …

Mitochondrial function in spinal cord injury and regeneration

PG Slater, ME Domínguez-Romero, M Villarreal… - Cellular and Molecular …, 2022 - Springer
Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Is graphene shortening the path toward spinal cord regeneration?

AF Girão, MC Serrano, A Completo, PAAP Marques - ACS nano, 2022 - ACS Publications
Along with the development of the next generation of biomedical platforms, the inclusion of
graphene-based materials (GBMs) into therapeutics for spinal cord injury (SCI) has potential …

Mesenchymal stem cells and the neuronal microenvironment in the area of spinal cord injury

YO Mukhamedshina, OA Gracheva… - Neural regeneration …, 2019 - journals.lww.com
Cell-based technologies are used as a therapeutic strategy in spinal cord injury (SCI).
Mesenchymal stem cells (MSCs), which secrete various neurotrophic factors and cytokines …

Ketogenic diet and ketone bodies against ischemic injury: targets, mechanisms, and therapeutic potential

CI Makievskaya, VA Popkov, NV Andrianova… - International journal of …, 2023 - mdpi.com
The ketogenic diet (KD) has been used as a treatment for epilepsy since the 1920s, and its
role in the prevention of many other diseases is now being considered. In recent years, there …

MCC950, a selective inhibitor of NLRP3 inflammasome, reduces the inflammatory response and improves neurological outcomes in mice model of spinal cord injury

J Jiao, G Zhao, Y Wang, P Ren, M Wu - Frontiers in molecular …, 2020 - frontiersin.org
Spinal cord injury (SCI) is a serious condition that affects bodily function; however, there is
no effective therapy in clinical practice. MCC950, a selective NOD-like receptor protein-3 …

MiRNAs as promising translational strategies for neuronal repair and regeneration in spinal cord injury

S Silvestro, E Mazzon - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) represents a devastating injury to the central nervous system (CNS)
that is responsible for impaired mobility and sensory function in SCI patients. The hallmarks …

Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury

R Zhao, X Wu, XY Bi, H Yang… - Neural Regeneration …, 2022 - journals.lww.com
Baicalin is a natural active ingredient isolated from Scutellariae Radix that can cross the
blood-brain barrier and exhibits neuroprotective effects on multiple central nervous system …