The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively
affected by the formation of tumor cell resistant clone and the severe toxicity of …

Bio-based nanomaterials have received considerable attention in cancer therapies due to
their potent characteristics such as autologous pharmaceutical, synergetic effects …

The design of bioactive supramolecular chirality is always hampered by the lack of feasible
schemes to assigned specific biological activities. Herein, we developed a “mirror-image …

A versatile breast cancer‐targeting nanocomposite therapeutic combining docetaxel (DXL),
polyvinyl alcohol (PVA) network for controlled release, and silica‐protected magnetic iron …

Introduction Chirality is immanent in nature, and chiral molecules can achieve their
pharmacological action through chiral matching with biomolecules and molecular …

Hematologic malignancies (HMs) pose a serious threat to patients' health and life, and the
five-year overall survival of HMs remains low. The lack of understanding of the pathogenesis …

Chirality in biomolecules is ubiquitous in our world, but oral nanomedicines constructed from
chiral peptides are extremely rare, principally because of the immature nanofabrication and …

Proteolysis-targeting chimeras (PROTACs) are molecules that selectively degrade a protein
of interest (POI). The incorporation of ligands that recruit mouse double minute 2 (MDM2) …

Since its discovery over 35 years ago, MDM2 has emerged as an attractive target for the
development of cancer therapy. MDM2's activities extend from carcinogenesis to immunity to …

Advances in the development of anti-tumour drugs and related technologies have resulted
in a significant increase in the number of cancer survivors. However, the incidence of …