ATP-binding cassette (ABC) transporters constitute one of the largest and most ancient
protein superfamilies found in all living organisms. They function as molecular machines by …

Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …

ABC transporters catalyze transport reactions, such as the high-affinity uptake of
micronutrients into bacteria and the export of cytotoxic compounds from mammalian cells …

P-glycoprotein or multidrug resistance protein (MDR1) is an adenosine triphosphate (ATP)
binding cassette transporter (ABCB1) intensely investigated because it is an obstacle to …

ABCB1 detoxifies cells by exporting diverse xenobiotic compounds, thereby limiting drug
disposition and contributing to multidrug resistance in cancer cells. Multiple small-molecule …

The multidrug transporter ABCB1 (P-glycoprotein) is an ATP-binding cassette transporter
that has a key role in protecting tissues from toxic insult and contributes to multidrug …

P-glycoprotein (P-gp) is a polyspecific ATP-dependent transporter linked to multidrug
resistance in cancer; it plays important roles in determining the pharmacokinetics of many …

Abstract ABCB1 (P-glycoprotein/P-gp) is an ATP-binding cassette transporter well known for
its association with multidrug resistance in cancer cells. Powered by the hydrolysis of ATP, it …

Antifungal resistance is a growing concern as it poses a significant threat to public health.
Fungal infections are a significant cause of morbidity and mortality, especially in …

Tuberculosis treatment requires months-long combination chemotherapy with multiple
drugs, with shorter treatments leading to relapses. A major impediment to shortening …