Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to a declaration of a
Public Health Emergency of International Concern by the World Health Organization. As of …

The prevalence of IBD is rising in the Western world. Despite an increasing repertoire of
therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in …

It has been shown that environmental factors such as infections, chemicals, and diet play a
major role in autoimmune diseases; however, relatively little attention has been given to …

The incidence and prevalence rate of chronic inflammatory disorders is on the rise in the
pediatric population. Recent research indicates the crucial role of interactions between the …

The retinoid nuclear receptor pathway, activated by the vitamin A metabolite retinoic acid,
has been extensively investigated for over a century. This study has resulted in conflicting …

The chemokine receptor CCR9 equips T cells with the ability to respond to CCL25, a
chemokine that is highly expressed in the thymus and the small intestine (SI). Notably …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestines without
a cure. Current therapies suppress inflammation to prevent further intestinal damage …

The recent emergence of engineered cellular therapies, such as Chimeric antigen receptor
(CAR) CAR T and T cell receptor (TCR) engineered T cells, has shown great promise in the …

Malignant melanoma has a high mutational rate. As a result, resistance to current therapies
is common. Consequently, there is an unmet medical need to develop novel therapies …

Regulatory T cells (Tregs) play a critical role in the maintenance of immune tolerance and
tumor evasion. However, the relative low proportion of these cells in peripheral blood and …