Acetaldehyde, the first product of ethanol metabolism, has been speculated to be involved in
many pharmacological and behavioral effects of ethanol. In particular, acetaldehyde has …

Acetaldehyde has long been suggested to be involved in a number of ethanol's
pharmacological and behavioral effects, such as its reinforcing, aversive, sedative, amnesic …

Ethanol non‐drinker (UChA) and drinker (UChB) rat lines derived from an original Wistar
colony have been selectively bred at the University of Chile for over 70 generations. Two …

Background: While the molecular entity responsible for the rewarding effects of virtually all
drugs of abuse is known, that for ethanol remains uncertain. Some lines of evidence suggest …

Fetal ethanol (E) exposure has well documented deleterious effects on brain development,
yet it is uncertain if the neurotoxicity of maternal E consumption is generated by E itself, by its …

Background A number of studies have shown that acetaldehyde synthesized in the brain is
necessary to induce ethanol (EtOH) reinforcement in naïve animals (acquisition phase) …

Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have
been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present …

This review analyzes literature that describes the behavioral effects of 2 metabolites of
ethanol (EtOH): acetaldehyde and salsolinol (a condensation product of acetaldehyde and …

This review represents an attempt to assess the available data on the role of catalase in the
mediation of the behavioral actions of ethanol and the regulation of voluntary ethanol …

Previous studies suggest that acetaldehyde generated from ethanol in the brain is
reinforcing. The present studies tested the feasibility of achieving a long‐term reduction of …