Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
The essential role of store-operated Ca 2+ entry (SOCE) through Ca 2+ release-activated
Ca 2+(CRAC) channels in T cells is well established. In contrast, the contribution of …
Ca 2+(CRAC) channels in T cells is well established. In contrast, the contribution of …
ALOX5 drives the pyroptosis of CD4+ T cells and tissue inflammation in rheumatoid arthritis
H Cai, J Zhang, H Xu, W Sun, W Wu, C Dong… - Science …, 2024 - science.org
Pyroptosis, an inflammatory form of programmed cell death, is linked to the pathology of
rheumatoid arthritis (RA). Here, we investigated the molecular mechanism underlying …
rheumatoid arthritis (RA). Here, we investigated the molecular mechanism underlying …
Blocking Orai1 constitutive activity inhibits B-cell cancer migration and synergistically acts with drugs to reduce B-CLL cell survival
J Scaviner, C Bagacean, B Christian… - European Journal of …, 2024 - Elsevier
Orai1 channel capacity to control store-operated Ca 2+ entry (SOCE) and B-cell functions is
poorly understood and more specifically in B-cell cancers, including human lymphoma and …
poorly understood and more specifically in B-cell cancers, including human lymphoma and …