Aging hallmarks and the role of oxidative stress

E Maldonado, S Morales-Pison, F Urbina, A Solari - Antioxidants, 2023 - mdpi.com
Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Radiation-induced salivary gland dysfunction: mechanisms, therapeutics and future directions

KJ Jasmer, KE Gilman, K Muñoz Forti… - Journal of clinical …, 2020 - mdpi.com
Salivary glands sustain collateral damage following radiotherapy (RT) to treat cancers of the
head and neck, leading to complications, including mucositis, xerostomia and …

Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture

M Riegman, L Sagie, C Galed, T Levin, N Steinberg… - Nature cell …, 2020 - nature.com
Ferroptosis is a regulated form of necrotic cell death that is caused by the accumulation of
oxidized phospholipids, leading to membrane damage and cell lysis,. Although other types …

Critical phenomena in complex networks

SN Dorogovtsev, AV Goltsev, JFF Mendes - Reviews of Modern Physics, 2008 - APS
The combination of the compactness of networks, featuring small diameters, and their
complex architectures results in a variety of critical effects dramatically different from those in …

Radiation-induced bystander signalling in cancer therapy

KM Prise, JM O'sullivan - Nature Reviews Cancer, 2009 - nature.com
Our understanding of how radiation kills normal and tumour cells has been based on an
intimate knowledge of the direct induction of DNA damage and its cellular consequences …

Radiation, inflammation and the immune response in cancer

KJ McKelvey, AL Hudson, M Back, T Eade… - Mammalian genome, 2018 - Springer
Radiation is an important component of cancer treatment with more than half of all patients
receive radiotherapy during their cancer experience. While the impact of radiation on tumour …

Cell-cell communication in the tumor microenvironment, carcinogenesis, and anticancer treatment

BLDM Brücher, IS Jamall - Cellular Physiology and Biochemistry, 2014 - karger.com
The delineation of key molecular pathways has enhanced our knowledge of the biology of
tumor microenvironment, tumor dissemination, and carcinogenesis. The complexities of cell …

Role of oxidatively induced DNA lesions in human pathogenesis

OA Sedelnikova, CE Redon, JS Dickey… - … Research/Reviews in …, 2010 - Elsevier
Genome stability is essential for maintaining cellular and organismal homeostasis, but it is
subject to many threats. One ubiquitous threat is from a class of compounds known as …

Mechanism of radiation-induced bystander effects: a unifying model

TK Hei, H Zhou, VN Ivanov, M Hong… - Journal of Pharmacy …, 2008 - academic.oup.com
The radiation-induced bystander effect represents a paradigm shift in our understanding of
the radiobiological effects of ionizing radiation, in that extranuclear and extracellular events …

Ferroptosis: Final destination for cancer?

Z Ye, W Liu, Q Zhuo, Q Hu, M Liu, Q Sun… - Cell …, 2020 - Wiley Online Library
Ferroptosis is a recently defined, non‐apoptotic, regulated cell death (RCD) process that
comprises abnormal metabolism of cellular lipid oxides catalysed by iron ions or iron …