Induced pluripotent stem cells in disease modelling and drug discovery
The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …
widespread enthusiasm for the development of new models of human disease, enhanced …
Induced pluripotent stem cells and their use in human models of disease and development
P Karagiannis, K Takahashi, M Saito… - Physiological …, 2019 - journals.physiology.org
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
GDF15 mediates the effects of metformin on body weight and energy balance
Metformin, the world's most prescribed anti-diabetic drug, is also effective in preventing type
2 diabetes in people at high risk,. More than 60% of this effect is attributable to the ability of …
2 diabetes in people at high risk,. More than 60% of this effect is attributable to the ability of …
Long-term culture of genome-stable bipotent stem cells from adult human liver
Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have …
systems available that sustain hepatocyte replication and/or function in vitro. We have …
Pluripotent stem cells in disease modelling and drug discovery
Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …
molecular mechanisms underlying diseases and the development of therapies for treating …
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond
The advent of human induced pluripotent stem cells (iPSCs) presents unprecedented
opportunities to model human diseases. Differentiated cells derived from iPSCs in two …
opportunities to model human diseases. Differentiated cells derived from iPSCs in two …
Lung regeneration: mechanisms, applications and emerging stem cell populations
DN Kotton, EE Morrisey - Nature medicine, 2014 - nature.com
Recent studies have shown that the respiratory system has an extensive ability to respond to
injury and regenerate lost or damaged cells. The unperturbed adult lung is remarkably …
injury and regenerate lost or damaged cells. The unperturbed adult lung is remarkably …
Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming
A Miyajima, M Tanaka, T Itoh - Cell stem cell, 2014 - cell.com
The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …
Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery
Recent progresses in the field of Induced Pluripotent Stem Cells (iPSCs) have opened up
many gateways for the research in therapeutics. iPSCs are the cells which are …
many gateways for the research in therapeutics. iPSCs are the cells which are …