Studies with temporal or spatial resolution are crucial to understand the molecular dynamics
and spatial dependencies underlying a biological process or system. With advances in high …

The evolution of gene expression in mammalian organ development remains largely
uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum …

Immunotherapy utilizing chimeric antigen receptor T cell (CAR-T) therapy holds promise for
hematologic malignancies, however, response rates and associated immune-related …

The immune system plays a vital role in health and disease, and is regulated through a
complex interactive network of many different immune cells and mediators. To understand …

Although regeneration through the reprogramming of one cell lineage to another occurs in
fish and amphibians, it has not been observed in mammals. We discovered in the mouse …

Although many long noncoding RNAs (lncRNAs) have been identified in human and other
mammalian genomes, there has been limited systematic functional characterization of these …

During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are
rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents …

Systemic lupus erythematosus (SLE) is prototypical autoimmune disease driven by
pathological T cell–B cell interactions,. Expansion of T follicular helper (TFH) and T …

We have produced an mRNA expression time course of zebrafish development across 18
time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos …

Drought represents a major threat to food security. Mechanistic data describing plant
responses to drought have been studied extensively and genes conferring drought …