Optimal control of nonequilibrium systems through automatic differentiation

MC Engel, JA Smith, MP Brenner - Physical Review X, 2023 - APS
Controlling the evolution of nonequilibrium systems to minimize dissipated heat or work is a
key goal for designing nanodevices, in both nanotechnology and biology. Progress in …

Advances in Pharmacokinetic Modelling and Computational Approaches for Nanoparticles in Drug Delivery Systems

S Dhoundiyal, MA Alam - … Recent Patents on Drug Delivery & …, 2023 - ingentaconnect.com
Generally, therapeutic drugs have issues like poor solubility, rapid removal from the
bloodstream, lack of targeting, and an inability to translocate across cell membranes. Some …

Probing the mechanical properties of DNA nanostructures with metadynamics

WT Kaufhold, W Pfeifer, CE Castro, L Di Michele - ACS nano, 2022 - ACS Publications
Molecular dynamics simulations are often used to provide feedback in the design workflow
of DNA nanostructures. However, even with coarse-grained models, the convergence of …

Measuring internal forces in single-stranded DNA: Application to a DNA force clamp

MC Engel, F Romano, AA Louis… - Journal of chemical …, 2020 - ACS Publications
We present a new method for calculating internal forces in DNA structures using coarse-
grained models and demonstrate its utility with the oxDNA model. The instantaneous forces …