Neuropsychopathology of autism spectrum disorder: complex interplay of genetic, epigenetic, and environmental factors
R Bhandari, JK Paliwal, A Kuhad - … food intervention and therapy for autism …, 2020 - Springer
Autism spectrum disorder (ASD) is a complex heterogeneous consortium of pervasive
development disorders (PDD) which ranges from atypical autism, autism, and Asperger …
development disorders (PDD) which ranges from atypical autism, autism, and Asperger …
Targeting mTOR for fighting diseases: A revisited review of mTOR inhibitors
T Xu, D Sun, Y Chen, L Ouyang - European journal of medicinal chemistry, 2020 - Elsevier
Abstract mTOR (mammalian target of rapamycin), which is a serine/threonine kinase, has
been well-established as being closely correlated with the occurrence of various human …
been well-established as being closely correlated with the occurrence of various human …
Cerebral organoid and mouse models reveal a RAB39b–PI3K–mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism …
Dysregulation of early neurodevelopment is implicated in macrocephaly/autism disorders.
However, the mechanism underlying this dysregulation, particularly in human cells, remains …
However, the mechanism underlying this dysregulation, particularly in human cells, remains …
Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism
E Rosina, B Battan, M Siracusano, L Di Criscio… - Translational …, 2019 - nature.com
The molecular signature underlying autism spectrum disorder remains largely unknown.
This study identifies differential expression of mTOR and MAPK pathways in patients …
This study identifies differential expression of mTOR and MAPK pathways in patients …
PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption
S Ladraa, L Zerbib, C Bayard, A Fraissenon… - Science …, 2022 - science.org
PIK3CA-related overgrowth syndrome (PROS) is a genetic disorder caused by somatic
mosaic gain-of-function mutations of PIK3CA. Clinical presentation of patients is diverse and …
mosaic gain-of-function mutations of PIK3CA. Clinical presentation of patients is diverse and …
Proteomic phenotype of cerebral organoids derived from autism spectrum disorder patients reveal disrupted energy metabolism, cellular components, and biological …
The way in which brain morphology and proteome are remodeled during embryonal
development, and how they are linked to the cellular metabolism, could be a key for …
development, and how they are linked to the cellular metabolism, could be a key for …
The gut-immune-brain axis in autism spectrum disorders; a focus on amino acids
Autism spectrum disorder (ASD) is a range of neurodevelopmental conditions that affect
communication and social behavior. Besides social deficits, systemic inflammation …
communication and social behavior. Besides social deficits, systemic inflammation …
BDNF, proBDNF and IGF-1 serum levels in naïve and medicated subjects with autism
MA Robinson-Agramonte, B Michalski… - Scientific Reports, 2022 - nature.com
Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) promote
the development and maintenance of neural circuits. Alterations in these factors might …
the development and maintenance of neural circuits. Alterations in these factors might …
[HTML][HTML] The role of PTEN in neurodevelopment
PD Skelton, RV Stan, BW Luikart - Molecular neuropsychiatry, 2019 - karger.com
PTEN is a lipid and protein phosphatase that regulates cell growth and survival. Mutations to
PTEN are highly penetrant for autism spectrum disorder (ASD). Here, we briefly review the …
PTEN are highly penetrant for autism spectrum disorder (ASD). Here, we briefly review the …
NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice
Autism spectrum disorders are neurodevelopmental conditions with diverse aetiologies, all
characterized by common core symptoms such as impaired social skills and communication …
characterized by common core symptoms such as impaired social skills and communication …