Image-guided nanotheranostics have the potential to represent a new paradigm in the
treatment of cancer. Recent developments in modern imaging and nanoparticle design offer …

Extracranial malignant rhabdoid tumors (extracranial MRT) are rare, highly aggressive
malignancies affecting mainly infants and children younger than 3 years. Common anatomic …

Rationale: Clinical interest in combining targeted radionuclide therapies (TRT) with
immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1 …

Triggered drug delivery strategies have been shown to enhance drug accumulation at target
diseased sites in comparison to administration of free drug. In particular, many studies have …

The utilization of nanotechnology has brought about notable advancements in the field of
pediatric medicine, providing novel approaches for drug delivery, disease diagnosis, and …

Rationale Murine syngeneic tumor models have revealed efficacious systemic antitumor
responses following primary tumor in situ vaccination combined with targeted radionuclide …

Background Systemic radiation treatments that preferentially irradiate cancer cells over
normal tissue, known as targeted radionuclide therapy (TRT), have shown significant …

Background: Osteosarcoma (OS) represents the most common primary bone tumor in
humans and in companion dogs, being practically phenotypically identical. There is a need …

Advanced ovarian cancer currently has few therapeutic options. Poly (ADP-ribose)
polymerase (PARP) inhibitors bind to nuclear PARP and trap the protein-inhibitor complex to …

We aim to evaluate the efficacy and safety of 124I-metaiodobenzylguanidine (MIBG)
dosimetry-guided high-activity 131I-MIBG therapy of advanced pheochromocytoma or …