Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses
LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …
shown the therapeutic potential effect of MSC or their derived products. However, the …
Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …
Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies
P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives
Mesenchymal stem cells (MSCs) are one of a few stem cell types to be applied in clinical
practice as therapeutic agents for immunomodulation and ischemic tissue repair. In addition …
practice as therapeutic agents for immunomodulation and ischemic tissue repair. In addition …
The current status of mesenchymal stromal cells: controversies, unresolved issues and some promising solutions to improve their therapeutic efficacy
D García-Bernal, M García-Arranz… - Frontiers in Cell and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) currently constitute the most frequently used cell type in
advanced therapies with different purposes, most of which are related with inflammatory …
advanced therapies with different purposes, most of which are related with inflammatory …
Use of mesenchymal stem cells for therapy of cardiac disease
V Karantalis, JM Hare - Circulation research, 2015 - Am Heart Assoc
Despite substantial clinical advances over the past 65 years, cardiovascular disease
remains the leading cause of death in America. The past 15 years has witnessed major …
remains the leading cause of death in America. The past 15 years has witnessed major …
Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue
S Golpanian, A Wolf, KE Hatzistergos… - Physiological …, 2016 - journals.physiology.org
Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …
Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions
SK Sanganalmath, R Bolli - Circulation research, 2013 - Am Heart Assoc
Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …
remains poor, and current therapeutic approaches are palliative in the sense that they do not …
Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers
BA Aguado, W Mulyasasmita, J Su… - … Engineering Part A, 2012 - liebertpub.com
Cell transplantation is a promising therapy for a myriad of debilitating diseases; however,
current delivery protocols using direct injection result in poor cell viability. We demonstrate …
current delivery protocols using direct injection result in poor cell viability. We demonstrate …
Paracrine mechanisms in adult stem cell signaling and therapy
Animal and preliminary human studies of adult cell therapy following acute myocardial
infarction have shown an overall improvement of cardiac function. Myocardial and vascular …
infarction have shown an overall improvement of cardiac function. Myocardial and vascular …