Maintenance of homeostatic immune surveillance and development of effective adaptive
immune responses require precise regulation of spatial and temporal lymphocyte trafficking …

Early studies have revealed that some mammalian plasma membrane proteins exist in small
nanoclusters. The advent of super-resolution microscopy has corroborated and extended …

Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma …

Integrins are recognized as vital players in leukocyte recruitment. Integrin malfunction
causes severe disease patterns characterized by the inability to fight pathogens. Although …

A successful immune response depends on the capacity of immune cells to travel from one
location in the body to another–these cells are rapid migrators, travelling at speeds of …

Exosomes are secreted vesicles formed in late endocytic compartments. Mature dendritic
cells (DCs) secrete exosomes bearing functional MHC-peptide complexes and high levels of …

The mechanisms that govern receptor coalescence into functional clusters—often a critical
step in their stimulation by ligand—are poorly understood. We used single-molecule tracking …

The role of mechanical properties in cancer disease and inflammation is still
underinvestigated and even ignored in many oncological and immunological reviews. In …

Recruitment of receptor proteins to lipid rafts has been proposed as an important
mechanism to regulate their cellular function. In particular, rafts have been implicated in …

Integrins comprise a large family of cell-cell and cell-matrix adhesion receptors that rapidly
modulate their adhesiveness. The arrest of leukocyte integrins on target vascular beds …