Triazoles are important five-membered heterocyclic scaffold due to their extensive biological
activities. This framework can be readily obtained in good to excellent yields on the …

Malaria, caused by protozoan parasites of the genus Plasmodium especially by the most
prevalent parasite Plasmodium falciparum, represents one of the most devastating and …

Malaria and cancer are chronic diseases. The challenge with drugs available for the
treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent …

Two exemplary contributions of organometallics in medicinal chemistry, ferroquine and
ferrocifen, which exhibit excellent anti-plasmodial and anti-cancer activities, respectively …

Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …

Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

Hybrid molecules have the potential to enhance the efficacy against both drug-sensitive and
drug-resistant organisms, and Ferroquine, a ferrocene hybrid, has demonstrated great …

Molecular hybridization is one of the recent stratagems in medicinal chemistry to synthesize
a novel hybrid molecule having better affinity and efficacy by combining two or more …

Abstract Twelve novel 1H-1, 2, 3-triazole-tethered gatifloxacin (GTFX) isatin conjugates 5a-l
with greater lipophilicity compared with GTFX were designed, synthesized and evaluated for …

A set of novel gatifloxacin-1H-1, 2, 3-triazole-isatin hybrids 6a-l was designed, synthesized
and evaluated for their in vitro anti-mycobacterial activities against M. tuberculosis (MTB) H …