The traditional view of cancer emphasizes a genes-first process. Novel cancer traits arise by
genetic mutations that spread to drive phenotypic change. However, recent data support a …

The clonal evolution model of cancer was developed in the 1950s–1970s and became
central to cancer biology in the twenty-first century, largely through studies of cancer …

Metastasis is a complex process that remains poorly understood at the molecular levels. We
profiled single-cell transcriptomic, genomic, and epigenomic changes associated with …

Drug resistance is a largely unsolved problem in oncology. Despite the explanatory power of
the genetic model of cancer initiation, most treatment resistance is unexplained by genetics …

Esophageal adenocarcinoma (EAC) is a highly lethal cancer of the upper gastrointestinal
tract with rising incidence in western populations. To decipher EAC disease progression and …

In paediatric cancers like neuroblastoma, limited genetic diversity emphasizes the role of
phenotypic heterogeneity in driving malignancy. We investigated this phenomenon using …

Organisms as well as cancer cells are adept at adapting to changes in the environment in
which they find themselves, by actively adjusting their phenotype. Phenotypic plasticity is a …