Epigenetics in renal cell cancer: mechanisms and clinical applications

SC Joosten, KM Smits, MJ Aarts, V Melotte… - Nature Reviews …, 2018 - nature.com
Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations.
By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic …

[HTML][HTML] The fundamental role of miR-10b in metastatic cancer

P Sheedy, Z Medarova - American journal of cancer research, 2018 - ncbi.nlm.nih.gov
Small, non-coding strands of RNA have been identified as a significant player in the
pathology of cancer. One of the first miRNAs to be shown as having aberrant expression in …

miR‐372 suppresses tumour proliferation and invasion by targeting IGF 2 BP 1 in renal cell carcinoma

X Huang, M Huang, L Kong, Y Li - Cell proliferation, 2015 - Wiley Online Library
Objectives Micro RNA s (mi RNA s) are endogenous small non‐coding RNA s that regulate
proteins and mRNA s for degradation or translational suppression. Up to now, the role of …

The level of circulating miRNA-10b and miRNA-373 in detecting lymph node metastasis of breast cancer: potential biomarkers

W Chen, F Cai, B Zhang, Z Barekati, XY Zhong - Tumor Biology, 2013 - Springer
MicroRNAs (miRNAs) are a class of small noncoding RNAs whose expression changes are
associated with cancer development and invasion. We hypothesized that miR-10b and miR …

[HTML][HTML] Pattern recognition for predictive, preventive, and personalized medicine in cancer

T Cheng, X Zhan - EPMA Journal, 2017 - Springer
Predictive, preventive, and personalized medicine (PPPM) is the hot spot and future
direction in the field of cancer. Cancer is a complex, whole-body disease that involved multi …

[HTML][HTML] MiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3

G Zhao, J Zhang, Y Shi, Q Qin, Y Liu, B Wang, K Tian… - PloS one, 2013 - journals.plos.org
Accumulating evidence indicates that microRNAs (miRNAs) are aberrantly expressed in
human cancer and contribute to the tumorigenesis, but their roles in pancreatic cancer are …

MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer

T Colangelo, A Fucci, C Votino, L Sabatino… - Neoplasia, 2013 - Elsevier
Abstract MicroRNA-130b (miR-130b) is involved in several biologic processes; its role in
colorectal tumorigenesis has not been addressed so far. Herein, we demonstrate that miR …

[HTML][HTML] Integrated microRNA and mRNA signature associated with the transition from the locally confined to the metastasized clear cell renal cell carcinoma …

Z Wotschofsky, L Gummlich, J Liep, C Stephan, E Kilic… - PloS one, 2016 - journals.plos.org
Background MicroRNAs (miRNAs) regulate gene expression by interfering translation or
stability of target transcripts. This interplay between miRNA and their mRNA has been …

[HTML][HTML] Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met

C Sun, M Sang, S Li, X Sun, C Yang, Y Xi, L Wang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract Hsa-miRNA-139-5p (miR-139-5p) has recently been discovered having anticancer
efficacy in different organs. However, the role of miR-139-5p on lung cancer is still …

The regulation and function of microRNAs in kidney diseases

Q Wei, QS Mi, Z Dong - IUBMB life, 2013 - Wiley Online Library
MicroRNAs (miRNA) are endogenous short noncoding RNAs, which regulate virtually all
major cellular processes by inhibiting target gene expression. In kidneys, miRNAs have …