This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

In the past decades an increasing number of studies revealed that G protein-coupled
receptors (GPCRs) are capable of forming dimers or even higher-ordered oligomers, which …

Recently, mixed opioid/NOP agonists came to the spotlight for their favorable functional
profiles and promising outcomes in clinical trials as novel analgesics. This study reports on …

Background and study aim Hepatocellular carcinoma (HCC) is the fifth leading cause of
cancer-related mortality worldwide, and, more than half of these cases are diagnosed in …

Pain impacts the lives of billions of people around the world–both directly and indirectly. It is
complex and transcends beyond an unpleasant sensory experience to encompass …

While low-dose cannabinoid 2 (CB2) receptor agonists attenuate morphine tolerance in
cancer pain models, chemokine ligand 12 (CXCL12)/chemokine receptor 4 (CXCR4) …