Biological insights from structures of two-component proteins

R Gao, AM Stock - Annual review of microbiology, 2009 - annualreviews.org
Two-component signal transduction based on phosphotransfer from a histidine protein
kinase to a response regulator protein is a prevalent strategy for coupling environmental …

Specificity in two-component signal transduction pathways

MT Laub, M Goulian - Annu. Rev. Genet., 2007 - annualreviews.org
Two-component signal transduction systems enable bacteria to sense, respond, and adapt
to a wide range of environments, stressors, and growth conditions. In the prototypical two …

Histidine protein kinases: key signal transducers outside the animal kingdom

PM Wolanin, PA Thomason, JB Stock - Genome biology, 2002 - Springer
Histidine protein kinases (HPKs) are a large family of signal-transduction enzymes that
autophosphorylate on a conserved histidine residue. HPKs form two-component signaling …

Genomic and transcriptomic analyses of colistin-resistant clinical isolates of Klebsiella pneumoniae reveal multiple pathways of resistance

MS Wright, Y Suzuki, MB Jones… - Antimicrobial agents …, 2015 - Am Soc Microbiol
The emergence of multidrug-resistant (MDR) Klebsiella pneumoniae has resulted in a more
frequent reliance on treatment using colistin. However, resistance to colistin (Colr) is …

The mechanism of signal transduction by two-component systems

P Casino, V Rubio, A Marina - Current opinion in structural biology, 2010 - Elsevier
Two-component systems, composed of a homodimeric histidine kinase (HK) and a response
regulator (RR), are major signal transduction devices in bacteria. Typically the signal …

Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria

GJ Lyon, RP Novick - Peptides, 2004 - Elsevier
There are two basic types of bacterial communication systems—those in which the signal is
directed solely at other organisms and those in which the signal is sensed by the producing …

Crystal structure of Pseudomonas aeruginosa bacteriophytochrome: Photoconversion and signal transduction

X Yang, J Kuk, K Moffat - Proceedings of the National …, 2008 - National Acad Sciences
Phytochromes are red-light photoreceptors that regulate light responses in plants, fungi, and
bacteria via reversible photoconversion between red (Pr) and far-red (Pfr) light-absorbing …

Structure of the entire cytoplasmic portion of a sensor histidine‐kinase protein

A Marina, CD Waldburger, WA Hendrickson - The EMBO journal, 2005 - embopress.org
The large majority of histidine kinases (HKs) are multifunctional enzymes having autokinase,
phosphotransfer and phosphatase activities, and most of these are transmembrane sensor …

Visualizing autophosphorylation in histidine kinases

P Casino, L Miguel-Romero, A Marina - Nature communications, 2014 - nature.com
Reversible protein phosphorylation is the most widespread regulatory mechanism in signal
transduction. Autophosphorylation in a dimeric sensor histidine kinase is the first step in two …

Individual and shared digital repertoires–older adults managing digital services

R Hänninen, L Pajula, V Korpela… - … Communication & Society, 2023 - Taylor & Francis
The rise of public and other non-recreational digital services is based on the idea of catering
to the daily needs of the citizens cost-efficiently and with ease. Previous research has …