There is a vast pre-clinical literature suggesting that certain nutraceuticals have the potential
to aid the preservation of bone mass in the context of estrogen withdrawal, glucocorticoid …

Background Nicotinamide adenine dinucleotide (NAD+), a coenzyme that plays crucial roles
in many cellular processes, is a potential therapeutic target for various diseases …

Age-related hearing loss (ARHL) is a major public health burden worldwide that profoundly
affects the daily life of elderly people. Silent information regulator 1 (SIRT1 or Sirtuin1) …

Abstract N6-methyl adenosine (m6A) modification is known to play a crucial role in various
aging-related diseases. However, its involvement in presbycusis, a type of age-related …

Presbycusis, also referred to as age-related hearing loss, poses a substantial burden on
both individuals and society. The hallmark of presbycusis is a progressive decrease in …

Aging causes progressive degenerative changes in many organs, particularly the auditory
system. Several attempts have been conducted to investigate preventive and therapeutic …

Age-related hearing loss (ARHL) is associated with hair cell apoptosis, but the underlying
mechanism of hair cell apoptosis remains unclear. Here, we investigated the expression …

Hearing loss is a health crisis that affects more than 60 million Americans. Currently, sodium
thiosulfate is the only drug approved by the Food and Drug Administration (FDA) to counter …

The pathogenesis of acne involves an excess of sebum production. Sebum is a fatty
substance produced by de novo lipogenesis (DNL) in sebocytes. A key driver of DNL is the …

ObjectiveTo study the protective effects of Erlong Zuoci Wan (ELZC) on cochlear spiral
ganglion neurons (SGNs) in mice with presbycusis and explore its mechanisms …