The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their
cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only …

BACKGROUND An increase in intrahepatic triglyceride (IHTG) is the hallmark feature of
nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo …

Obesity and its associated comorbidities are among the most prevalent and challenging
conditions confronting the medical profession in the 21st century. A major metabolic …

Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which
transcriptionally activates genes involved in FA synthesis, whereas glucose activates …

Insulin resistance is a key feature of the metabolic syndrome and often progresses to type 2
diabetes. Both insulin resistance and type 2 diabetes are characterized by dyslipidemia …

Hepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active
lipogenesis. Hepatic lipogenesis depends on the insulin-induced activation of the …

The liver provides for long-term energy needs of the body by converting excess
carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but …

Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made
towards elucidating the mechanisms controlling the major regulatory pathways are now …

Nonalcoholic fatty liver disease occurs frequently in the setting of metabolic syndrome, but
the factors leading to nonalcoholic steatohepatitis (NASH) are not fully understood. This …