Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Mammalian homologues of the Drosophila transient receptor potential (TRP) channel gene
encode a family of at least 20 ion channel proteins. They are widely distributed in …

The transient receptor potential (TRP) protein superfamily consists of a diverse group of
cation channels that bear structural similarities to Drosophila TRP. TRP channels play …

Upon fertilisation by sperm, mammalian eggs are activated by a series of intracellular Ca2+
oscillations that are essential for embryo development. The mechanism by which sperm …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Phosphoinositide-specific phospholipase C is an effector molecule in the signal transduction
process. It generates two second messengers, inositol-1, 4, 5-trisphosphate and …

Mammalian fertilization comprises sperm migration through the female reproductive tract,
biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct …

Abstract Inositol 1, 4, 5‐trisphosphate (IP3) is a second messenger that induces the release
of Ca2+ from the endoplasmic reticulum (ER). The IP3 receptor (IP3R) was discovered as a …

The transient receptor potential (TRP) protein superfamily consists of a diverse group of
Ca2+ permeable nonselective cation channels that bear structural similarities to Drosophila …

Intracellular Ca 2+ stores play a central role in the regulation of cellular [Ca 2+] i and the
generation of complex [Ca 2+] signals such as oscillations and waves. Ca 2+ signalling is of …