Natural Polymorphisms of integrase Among HIV Type 1-Infected South African Patients

MQ Fish, R Hewer, CL Wallis, WDF Venter… - AIDS research and …, 2010 - liebertpub.com
An HIV-1 subtype C specific assay was established for integrase genotyping from 51
integrase inhibitor-naive patient plasma samples and 22 antiretroviral drug-naive primary …

Documentation of subtype C HIV type 1 strains in Argentina, Paraguay, and Uruguay

G Carrion, L Eyzaguirre, SM Montano… - AIDS Research & …, 2004 - liebertpub.com
HIV subtypes B, F, and BF recombinants have been previously reported in South America.
This report describes the presence of HIV-1 subtype C infection in the countries of Argentina …

Genetic diversity and naturally polymorphisms in HIV type 1 integrase isolates from Maputo, Mozambique: implications for integrase inhibitors

MF Oliveira, DB Ramalho, CM Abreu… - AIDS research and …, 2012 - liebertpub.com
HIV proviral DNA integration into the host chromosome is carried out by integrase becoming
an important target antiretroviral therapy. Raltegravir was the first integrase inhibitor …

Molecular characterization of non-subtype C and recombinant HIV-1 viruses from Cape Town, South Africa

E Wilkinson, S Engelbrecht - Infection, Genetics and Evolution, 2009 - Elsevier
HIV was first diagnosed within South Africa in 1982. Homosexual transmission of HIV-1
dominated the epidemic within the country in the early stages of the 1980s. Currently …

[HTML][HTML] Cellular specificity of HIV-1 replication can be controlled by LTR sequences

E Reed-Inderbitzin, W Maury - Virology, 2003 - Elsevier
Two well-established determinants of retroviral tropism are envelope sequences that
regulate entry and LTR sequences that can regulate viral expression in a cell-specific …

Identification of a new 2‐amino acid insertion in the integrase coding region of HIV‐1 subtype G isolates

J Pereira‐Vaz, P Crespo, L Mocho… - Journal of Medical …, 2021 - Wiley Online Library
Amino acid insertions have been rarely found in the integrase (IN) coding region of Human
immunodeficiency virus 1 (HIV‐1), and have been considered as natural polymorphisms. It …

Characterization of HIV-1 subtype B near full-length genome sequences identified at the start of HIV epidemic in South Africa

AE Obasa - 2017 - scholar.sun.ac.za
Abstract ENGLISH SUMMARY: South Africa is home to approximately 20.0% of the global
Human Immunodeficiency Virus (HIV) infected population. The first reported cases of HIV-1 …

[DOC][DOC] How to use efficiently the world's scarce selenium resources to improve the global health situation.

A Haug, RD Graham, GH Lyons, OA Christophersen… - researchgate.net
The geochemistry and biogeochemistry of selenium (Se) are surveyed and possible
cosmochemical or geochemical reasons for the scarcity of selenium in the Earth's crust are …

[PDF][PDF] FC gamma receptors: genetic variation and role in HIV-1 infection

MM Lassaunière - 2015 - wiredspace.wits.ac.za
Low affinity Fcγ receptors (FcγR) mediate key immune effector mechanisms through the
engagement of the Fc portion of immunoglobulin G (IgG). These receptors are involved in …

[PDF][PDF] Mechanisms underlying reductions in mother-to-child transmission of human immunodeficiency virus type-1 by short-course antiretrovirals

DB Schramm - 2007 - core.ac.uk
Knowledge of the timing of mother-to-child transmission (MTCT) of HIV-1 is an important
issue in reducing the risk of infant infection. Prior to giving birth therefore an HIV-1 positive …