Major life stressors, especially those involving interpersonal stress and social rejection, are
among the strongest proximal risk factors for depression. In this review, we propose a …

Cytokines have been implicated in the pathology of depression. Currently, the evidence is
based on cross-sectional studies and meta-analytic research comparing blood …

BACKGROUND: Major depression occurs in 4.4% to 20% of the general population. Studies
suggest that major depression is accompanied by immune dysregulation and activation of …

Major depressive disorder (MDD) is a heterogeneous disease affecting one out of five
individuals and is the leading cause of disability worldwide. Presently, MDD is considered a …

The first findings that depression is characterized by cell-mediated immune activation and
inflammation were published between 1990–1993 (Maes et al.). Recently, it was reported …

Major depressive disorder (MDD) is characterized by mood, vegetative, cognitive, and even
psychotic symptoms and signs that can cause substantial impairments in quality of life and …

Brackground We aimed to examine associations between elevated symptoms of depression
and anxiety and disease activity in inflammatory bowel disease (IBD). Previous findings …

There is by now substantial clinical evidence for an association between specific mood
disorders and altered immune function. More recently, a number of hypotheses have been …

Despite significant research efforts aimed at understanding the neurobiological
underpinnings of psychiatric disorders, the diagnosis and the evaluation of treatment of …

Major depression and chronic pain are significant health problems that seriously impact the
quality of life of affected individuals. These diseases that individually are difficult to treat …