Radiotherapy combined with immunotherapy: the dawn of cancer treatment
Z Zhang, X Liu, D Chen, J Yu - Signal Transduction and Targeted …, 2022 - nature.com
Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …
CAR-NK cells: A promising cellular immunotherapy for cancer
Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …
Stereotactic ablative radiotherapy for operable stage I non-small-cell lung cancer (revised STARS): long-term results of a single-arm, prospective trial with prespecified …
JY Chang, RJ Mehran, L Feng, V Verma, Z Liao… - The Lancet …, 2021 - thelancet.com
Background A previous pooled analysis of the STARS and ROSEL trials showed higher
survival after stereotactic ablative radiotherapy (SABR) than with surgery for operable early …
survival after stereotactic ablative radiotherapy (SABR) than with surgery for operable early …
Stereotactic ablative radiotherapy with or without immunotherapy for early-stage or isolated lung parenchymal recurrent node-negative non-small-cell lung cancer: an …
JY Chang, SH Lin, W Dong, Z Liao, SJ Gandhi, CM Gay… - The Lancet, 2023 - thelancet.com
Background Stereotactic ablative radiotherapy (SABR) is the standard treatment for
medically inoperable early-stage non-small-cell lung cancer (NSCLC), but regional or …
medically inoperable early-stage non-small-cell lung cancer (NSCLC), but regional or …
Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2, open …
Background The oligometastatic paradigm suggests that some patients with a limited
number of metastases might be cured if all lesions are eradicated. Evidence from …
number of metastases might be cured if all lesions are eradicated. Evidence from …
Immunogenic cell death induction by ionizing radiation
M Zhu, M Yang, J Zhang, Y Yin, X Fan… - Frontiers in …, 2021 - frontiersin.org
Immunogenic cell death (ICD) is a form of regulated cell death (RCD) induced by various
stresses and produces antitumor immunity via damage-associated molecular patterns …
stresses and produces antitumor immunity via damage-associated molecular patterns …
Using immunotherapy to boost the abscopal effect
More than 60 years ago, the effect whereby radiotherapy at one site may lead to regression
of metastatic cancer at distant sites that are not irradiated was described and called the …
of metastatic cancer at distant sites that are not irradiated was described and called the …
Metformin promotes antitumor immunity via endoplasmic-reticulum-associated degradation of PD-L1
Metformin has been reported to possess antitumor activity and maintain high cytotoxic T
lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of …
lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of …
The complementarity of DDR, nucleic acids and anti-tumour immunity
Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
Prospects for combining targeted and conventional cancer therapy with immunotherapy
P Gotwals, S Cameron, D Cipolletta… - Nature Reviews …, 2017 - nature.com
Over the past 25 years, research in cancer therapeutics has largely focused on two distinct
lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous …
lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous …