Vascular calcification contributes to the high risk of cardiovascular mortality in chronic kidney
disease (CKD) patients. Dysregulation of calcium (Ca) and phosphate (P) metabolism is …

The metabolically active and perpetually remodeling calcium phosphate–based
endoskeleton in terrestrial vertebrates sets the demands on whole-organism calcium and …

Exercise perturbs homeostasis, alters the levels of circulating mediators and hormones, and
increases the demand by skeletal muscles and other vital organs for energy substrates …

Observational studies have determined hyperphosphatemia to be a cardiovascular risk
factor in chronic kidney disease. Mechanistic studies have elucidated that …

Parathyroid hormone (PTH) is the major secretory product of the chief cells of the
parathyroid glands, and the human gene encoding PTH is located on chromosome 11. 1 …

The mammalian kidney is multiform. The basic architecture is best understood in the
unipapillary kidney, which is common in all small species. A coronal section of this kidney …

Transport of phosphate across intestinal and renal epithelia is essential for normal
phosphate balance, yet we know less about the mechanisms and regulation of intestinal …

Phosphate is an essential nutrient for life and is a critical component of bone formation, a
major signaling molecule, and structural component of cell walls. Phosphate is also a …

Inorganic phosphate (Pi) is required for energy metabolism, nucleic acid synthesis, bone
mineralization, and cell signaling. The activity of cell-surface sodium-phosphate (Na+-Pi) …

Members of the SLC34 gene family of solute carriers encode for three Na+-dependent
phosphate (P i) cotransporter proteins, two of which (NaPi-IIa/SLC34A1 and NaPi …